Safety

Sixty-day antibiotic therapy may not prevent anthrax infection

Emergency Management Alert, August 6, 2003

Future anthrax outbreaks may require more than 60 days of antibiotic therapy to prevent infection, Reuters reports.

A study published in the July 28th edition of the Proceedings of the National Academy of Sciences studied the 60-day therapy given to people exposed to anthrax in the 2001 outbreak. The researchers found that 60 days of antibiotics may not be enough to prevent the disease in some outbreaks involving higher levels of exposure to anthrax. In the event of a massive attack with high-spore doses, a minimum of four months of therapy would be required.

By looking at the rates of illness at an outbreak's start, researchers found they could calculate the anthrax dose that victims were exposed to, and determine the proper duration of treatment. The researchers were led by Ron Brookmeyer, PhD, of Johns Hopkins Bloomberg School of Public Health in Baltimore.

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