Researchers identify new risk factor for DVT
Hospitalist Leadership Connection, September 11, 2007
Britain's Journal of Thrombosis and Haemostasis recently published the results of a retrospective study finding that the presence of anti-EPCR autoantibodies is a moderate risk factor for deep-venous thrombosis (DVT) in the general population. Anti-EPCR autoantibodies have been associated with fetal death and myocardial infarction in young women, according to the study's abstract.
The study measured plasma anti-EPCR autoantibody levels within the larger Leiden Thrombophilia Study (LETS), a population-based case-control study consisting of 474 patients with a first DVT and 474 control subjects.
The estimated risk of DVT was increased approximately twofold in the presence of elevated IgA, IgG, or IgM anti-EPCR autoantibodies (i.e., levels above the 90th percentile as measured in the control subjects).
Citation: van Hylckama Vlieg A, Montes R, Rosendaal FR, Hermida J. Autoantibodies against endothelial protein C receptor and the risk of a first deep vein thrombosis. J Thromb Haemost 2007;5:1449-1454.
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