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Study: Protein IKKa inhibits immune response to bacterial infections

Infection Control Monitor, April 29, 2005

Researchers have identified a protein which is responsible for shutting down the immune response to invading pathogens. Scientists may use this information in the treatment of infections like methicillin-resistant Staphylococcus aureus.

The study, which the University of California at San Diego conducted, revealed that when the protein IKKa is inhibited, the human body's response to infection strengthens. IKKa also reduces inflammation.

Scientists studied mice without IKKa and found a significant increase in the killing of bacteria. However, inflammation was higher than in normal mice. Researchers believe IKKa's role in inflammation can also aid in the future treatment of arthritis.

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